Posts tagged ‘biotech’
Marathon Market Gets a Cramp
This article is an excerpt from a previously released Sidoxia Capital Management complimentary newsletter (October 1, 2015). Subscribe on the right side of the page for the complete text.
“Anyone can run a hundred meters, it’s the next forty-two thousand and two hundred that count.”
Investing is a lot like running a marathon…but it’s not a sprint to the retirement finish line. The satisfaction of achieving your long-term goal can be quite rewarding, but attaining ambitious objectives does not happen overnight. Along the hilly and winding course, there can be plenty of bumps and bruises mixed in with the elation of a runner’s high. While stocks have been running at a record pace in recent years, prices have cramped up recently as evidenced by the -2.6% decline of the S&P 500 stock index last month.
But the recent correction should be placed in the proper perspective as you approach and reach retirement. Since the end of the 2008 Financial Crisis the stock market has been racing ahead at a brisk rate, as you can see from the total return performance below (excluding 2015):
This performance is more indicative of a triumph than a catastrophe, but if you turned on the TV, listened to the radio, or surfed the web, you may come to a more frightening conclusion.
What’s behind the recent dip? These are some of the key concerns driving the recent price volatility:
- China: Slowing growth in China and collapse in Chinese stock market. China is suffering from a self-induced slowdown designed to mitigate corruption, prick the real estate bubble, and shift its export-driven economy to a more consumer-driven economy. These steps diminish short-term growth (albeit faster than U.S. growth), but nevertheless the measures should be constructive for longer-term growth.
- Interest Rates: Uncertainty surrounding the timing of a 0.25% target interest rate increase by the Federal Reserve. The move from 0% to 0.25% is like walking from the hardwood floor onto the rug…hardly noticeable. The inevitable move by the Fed has been widely communicated for months, and given where interest rates are today, the move will have a negligible impact on corporate borrowing costs. Like removing a Band-Aid, the initial action may cause some pain, but should be comfortably received shortly thereafter.
- Politics: Potential government shutdown / sequestration. The epic political saga will never end, however, as I highlighted in “Who Said Gridlock is Bad?,” political discourse in Washington has resulted in positive outcomes as it relates to our country’s fiscal situation (limited government spending and declining deficits). The government shutdown appears to have been averted for now, but it looks like we will be blanketed with brinkmanship nonsense again in a few months.
- Biotech/Pharmaceuticals: Politics over lofty drug prices and the potential impact of future regulation on the biotech sector. Given the current Congressional balance of power, any heavy-handed Democratic proposals is likely to face rigorous Republican opposition.
- Emerging Markets: Emerging market weakness, especially in Latin America (e.g., Brazil). These developments deserve close monitoring, but the growth in the three largest economic regions (U.S., Europe, and China) will have a much larger effect on the direction of global economic expansion.
- Middle East: Destabilized Middle East and Syria. Terrorist extremism and cultural animosity between various Middle East populations has existed for generations. There will be no silver bullet for a peaceful solution, so baby steps and containment are critical to maintain healthy global trade activity with minimal disruptions.
Worth noting, this current list of anxieties itemized above is completely different from six months ago (remember the Greece crisis?), and the list will change again six months into the future. Investing, like any competitive challenge, does not come easy…there is always something to worry about in the land of economics and geopolitics.
Here’s what the world’s top investor Warren Buffett said a few decades ago (1994) on the topic of politics and economics:
“We will continue to ignore political and economic forecasts which are an expensive distraction for investors and businessmen. Thirty years ago, no one could have foreseen the huge expansion of the Vietnam War, wage and price controls, two oil shocks, the resignation of a president, the dissolution of the Soviet Union, a one-day drop in the Dow of 508 points, or treasury bill yields fluctuating between 2.8% and 17.4%.”
In a world of 7.3 billion people and 196 countries there will never be a shortage of fear, uncertainty, and doubt (F.U.D.) – see events chart in The Bungee Market. In an ever-increasing, globally connected world, technology and the media continually amplify molehills into mountains, thereby making the next imagined Armageddon a simple click of a mouse or swipe of a smartphone away.
Today’s concerns are valid but in the vast majority of cases the issues are completely overblown, sensationalized and over-emphasized without context. Context is an integral part to investing, but unfortunately context usually cannot be explained in a short soundbite or headline. On the flip side, F.U.D. thrives in the realm of soundbites and headlines.
While investors may feel fatigued from a strong flow of headline headwinds, financial market race participants should take a break at the water stop to also replenish themselves with a steady tailwind of positive factors, including the following:
- Employment: The unemployment rate has been cut from a recession peak of 10.0% down to 5.1%, and the economy has been adding roughly +200,000 new monthly jobs on a fairly consistent basis. On top of that, there are a record 5.8 million job openings versus 3.7 million two years ago – a sign that the economy continues to hum along.
- Housing/Commercial Real Estate/Mortgage Rates: Housing prices have rebounded by about +30% from the 2012 lows; Housing starts have increased by +25% in the past year and 120% in the past four years; and 30-Year Fixed mortgage interest rates sit at 3.85% – a highly stimulative level within a spitting distance from record lows.
- Auto Sales: Surged to a post-recession record of 17.8 million units in August.
- Interest Rates: Massively stimulative and near generational lows, even if the Fed hikes its interest rate target by 0.25% in October, December or sometime in 2016.
- Capital Goods Orders: Up for three consecutive months.
- Rail Shipments/Truck Tonnage: Both these metrics are rising by about 3-4%.
- Retail Sales: Rising at a very respectable pace of 7% over the last six months.
- Low Energy & Commodity Prices: Inflation has remained largely in check thanks to plummeting commodity prices. Low oil and gas prices are benefiting consumers in numerous ways, including the contribution to car sales, home sales, and/or debt reduction.
While the -10% dip in stock prices from mid-August might feel like a torn knee ligament, long-term investors know -10% corrections historically occur about one-time per year, on average. So, even though you may be begging for a wheelchair, the best course of action is to take a deep breath, stick to your long-term investment plan, rebalance your portfolio if necessary, and continue staying on course towards your financial finish line.
Wade W. Slome, CFA, CFP®
Plan. Invest. Prosper.
DISCLOSURE: Sidoxia Capital Management (SCM) and some of its clients hold positions in certain exchange traded funds (ETFs) , but at the time of publishing, SCM had no direct position in any other security referenced in this article. No information accessed through the Investing Caffeine (IC) website constitutes investment, financial, legal, tax or other advice nor is to be relied on in making an investment or other decision. Please read disclosure language on IC Contact page.
Hunting for Tennis Balls and Dead Cats
When it comes to gravity, people understand what goes up, must come down. But the reverse is not always true for stocks. What goes down, does not necessarily need to come back up. Since the 2008-09 financial crisis there have been a large group of multi-billion dollar behemoth stocks that have defied gravity, but over the last few months, many of these highfliers have come back to earth. Despite the pause in some of these major technology, consumer, and internet stocks, the overall stock market appears relatively calm. In fact, the Dow Jones Industrials index is currently sitting at all-time record highs and the S&P 500 index is hovering around -1% from its peak. But below the surface, there is a large undercurrent resulting in an enormous rotation out of pricier momentum and growth stocks into more defensive and yield-heavy sectors of the market, like utilities and real estate.
To expose this concealed trend I have highlighted a group of 20 stocks below, valued at close to half a trillion dollars. Over the last 12 months, this selective group of technology, consumer, and internet stocks have lost over -$200,000,000,000 from their peak values. Here’s a look at the highlighted stocks:
With respect to all the punished stocks, the dilemma for investors amidst this depreciating price carnage is how to profitably hunt for the bouncing tennis balls while avoiding the dead cat bounces. By hunting bouncing tennis balls, I am referring to the identification of those companies that have crashed from indiscriminate selling, even though the companies’ positive business fundamentals remain fully intact. The so-called dead cats reflect those overpriced companies that lack the earnings power or trajectory to support a rebounding stock price. Like a cat falling from a high-rise building, there may exist a possibility of a small rebound, but for many severely broken momentum stocks, minor bounces are often short-lived.
For long-term investors, much of the recent rotation is healthy. Some of the froth I’ve been writing about in the biotech, internet, and technology has been mitigated. As a result, in many instances, outrageous or rich stock valuations have now become fairly priced or attractive.
Profiting from Collapses
Many investors do not realize that some of the greatest stocks of all-time have suffered multiple -50% drops before subsequently doubling, tripling, quadrupling or better. History provides many rebounding tennis ball examples, but let’s take a brief look at the Apple Inc. (AAPL) chart from 1980 – 2005 to drive home the point:
As you can see, there were at least five occasions when the stock got chopped in half (or worse) over the selected timeframe and another five occasions when the stock doubled (or better), including a +935% explosion in the 1997–2000 period, and a +503% advance from 2002–2005 when shares reached $45. The numbers get kookier when you consider Apple’s share price eventually reached $700 and closed early last week above $600.
These feast and famine patterns can be discovered for virtually all of the greatest all-time stocks. The massive volatility explains why it’s so difficult to stick with theses long-term winners. A more recent example of a tennis ball bounce would be Facebook Inc (FB). The -58% % plummet from its $42 IPO peak has been well-documented, and despite the more recent -21% pullback, the stock is still up +223% from its $18 lows.
On the flip side, an example of a dead cat bounce would include Cisco Systems Inc (CSCO). After the bursting of the 2000 technology bubble, Cisco has never fully recovered from its $82 peak value. There have been many fits and starts, including some periods of 50% declines and 100% gains, but due to excessive valuations in the late 1990s and changing competitive trends, Cisco still sits at $23 today (see chart below).
It is important to remember that just because a stock goes down -50% in value doesn’t mean that it’s going to double or triple in value in the future. Price momentum can drive a stock in the short run, but in the long run, the important variables to track closely are cash flows and earnings (see It’s the Earnings, Stupid) . The level and direction of these factors ultimately correlate best with the ultimate fair value of stock prices. Therefore, if you are fishing in the growth or momentum stock pond, make sure to do your homework after a stock price collapses. It’s imperative that you carefully hunt down rebounding tennis balls and avoid the dead cat bounces.
Wade W. Slome, CFA, CFP®
Plan. Invest. Prosper.
DISCLOSURE: Sidoxia Capital Management (SCM) and some of its clients hold long positions in certain exchange traded funds (ETFs), AMZN, long NFLX bond, short NFLX stock, short LULU, and long CSCO (in a non-discretionary account), but at the time of publishing SCM had no direct position in TWTR, GRPN, YELP, ATHN, AVP, P, LNKD, BBY, ZNGA, WDAY, WFM, N, SSYS, JDSU, COH, CRM, FB or any other security referenced in this article. No information accessed through the Investing Caffeine (IC) website constitutes investment, financial, legal, tax or other advice nor is to be relied on in making an investment or other decision. Please read disclosure language on IC Contact page.
Investing, Housing, and Speculating
We all know there was a lot of speculation going on in the housing market during 2005-2007 as risk-loving adventurists loaded up on NINJA loans (No Income, No Job, and No Assets) and subprime CDS (Credit Default Swap) securities. But there is a different kind of speculation going on now, and it isn’t tied directly to housing. Instead of buying a house with no down payment and a no interest loan, speculators are leaping into other hazardous areas of danger. Like a frog jumping from lily pad to lily pad, speculators are now hopping around onto money-chasing industries, including biotech, social media, Bitcoin, and alternative energy.
As French novelist Jean-Baptise Alphonse Karr noted, “The more things change, the more they stay the same.” Irrespective of the painful consequences of the bubble-bursting aftermaths, human behavior and psychology addictively succumb to the ever-seductive emotion of greed. Over the last 15 years, massive fortunes have been gained and lost while chasing frothy financial dreams in areas like technology, housing, and gold.
Most get-rich-quick dream chasers have no idea of how to invest in or value a stock, but they sure know a good story when they hear one. Chasing top performing stocks is lot like jumping off a bridge – anyone can do it, and it feels exhilarating until you hit the ground. However, there is a better way to create wealth. Despite rampant speculation, most individuals understand the principles behind buying a house, which if applied to stocks, can make you a superior investor, and assist you in avoiding dangerous, speculative investments.
Here are some valuable housing insights to improve your stock buying:
#1.) Price is the Almighty Variable: Successful real estate investors don’t make their fortunes by chasing properties that double or triple in value. Buying a rusty tool shed for $1 million makes about as much sense as Facebook paying $19 billion (1,000 x’s the estimated 2013 annual revenues) for a money-losing company, WhatsApp. Better to buy real estate when there is blood in the street. Like the stock market, housing is cyclical. Many traders believe that price patterns are more important than the actual price. If squiggly, technical price moving averages (see Technical Analysis article) make so much money for stock-renting speculators, then how come day traders haven’t used their same crossing-lines and Point & Figure software in the housing market? Yes, it’s true that the real estate transactions costs and illiquidity can be costly for real estate buyers, but 6% load fees, lockup periods, 20% hedge fund fees, and 9% margin rates haven’t stopped stock speculators either.
#2). Cash is King: It doesn’t take a genius to purchase a rental property – I know because practically half the people I know in Southern California own rental properties. For example, if I buy a rental property for $1 million cash, is it a good purchase? Well, it depends on how much after-tax cash I can collect by renting it out? If I can only net $3,000 per month (3.6% annualized return), and be responsible for replacing roofs, fixing toilets, and evicting tenants, then perhaps I would be better off by collecting 6.5% from a low-cost, tax-efficient exchange traded real estate fund, without having to suffer from all the headaches that physical real estate investing brings. Forecasting future asset price appreciation is tougher, but the point is, understanding the underlying cash flow dynamics of a company is just as important as it is for housing purchases.
#3). Debt/Leverage Cuts in Both Directions: Adding debt (or leverage) to a housing or stock investment can be fantastic if prices go up, and disastrous if prices go down. Putting a 20% down payment on a $1 million house works out wonderfully, if the price of the house increases to $1.2 million. My $200,000 down payment is now worth $400,000, or up +100%. The same math works in reverse. If the price of the home drops to $800,000, then my $200,000 down payment is now worth $0, or down -100% (ouch). Margin debt on an equity brokerage account works in a similar fashion, but usually a 50% down payment is needed (less risky than real estate). That’s why I always chuckle when many real estate investors tell me they steer clear of stocks because they are “too risky”.
#4). Growth Matters: If you buy a home for $1 million, is it likely to be worth more if you add a kitchen, tennis court, swimming pull, third floor, and putting green? In short, the answer is yes. The same principle applies to stocks. All else equal, if a company based in Los Angeles, establishes new offices in New York, London, Beijing, and Rio de Janeiro, and then acquires a profitable competitor at a discounted price, chances are the company will be much more valuable after the additions. The key concept here is that asset values are not static. Asset valuations are impacted in both directions, whether we are talking about positive growth opportunities or negative disruptions.
Overall, speculatively chasing performance is tempting, but if you don’t want your financial foundation to crumble, then build your successful investment future by sticking to the fundamentals and financial basics.
Wade W. Slome, CFA, CFP®
Plan. Invest. Prosper.
DISCLOSURE: Sidoxia Capital Management (SCM) and some of its clients hold long positions in certain exchange traded funds (ETFs), but at the time of publishing SCM had no direct discretionary position in FB, Bitcoin, or any other security referenced in this article. No information accessed through the Investing Caffeine (IC) website constitutes investment, financial, legal, tax or other advice nor is to be relied on in making an investment or other decision. Please read disclosure language on IC Contact page.
Market Expands and So Does Sidoxia’s Team
This article is an excerpt from a previously released Sidoxia Capital Management complementary newsletter (March 3, 2014). Subscribe on the right side of the page for the complete text.
After a brief pause at the beginning of the year, the stock market built on the tremendous gains of 2013 (S&P 500 up +30%) by reaching record highs again in February by expanding another +4.3% for the month. My investment management and financial planning firm, Sidoxia Capital Mangement, LLC, has been expanding as well. Just this last month, we added a key investment and financial planning professional (Keith C. Bong, CFA, CPA Press Release) with more than 25 years of experience in the fields.
The Record Setting Advance Continues
Now entering the sixth year of this record setting bull market, many investors and pundits have been surprised by the strength and duration of the advance. At the nadir of the financial crisis, the stock market reached a multi-year low of 666 on March 9, 2009. For comparison purposes, the S&P 500 recently closed at 1,845, almost tripling in value since the crisis lows. Pessimists and skeptics, who locked in losses during the crisis plunge, have watched the explosive gains while sitting on their hands. While I freely admit, the low-hanging fruit has been picked, many of the doubters are still calling for a collapse as “troubling news continues to pour in from all over the planet.” However, what the naysayers neglect to acknowledge is the fact that S&P 500 reported profits, the lifeblood of bull markets, have also tripled in value. Despite what the bears say, not everything is a speculative house of cards.
Late to the Party Because of Uncertainty
Although the stock party has lasted five years thus far, individuals have only begun buying for about one year (see ICI fund flows data in Here Comes the Dumb Money) – about +$28 billion of new money in 2013 and another +$12 billion so far this year (ICI data through February 19th). After approximately six years and -$600 billion in stock sales (2007-2012), it’s no wonder investors have been slow to reverse course. Adding to the angst, investors have been bombarded with an endless stream of political and economic concerns on a daily basis, leading to the late arrival of most individuals to the stock investing party. While it’s true that more people have joined the party in recent months, floods of investors are still waiting outside in the cold. Here are a few reasons for the tardiness:
- Geopolitical Concerns: Most recently it was Syria, Iran, and Argentina that got short-term traders chewing their fingernails…now it’s the Ukraine. Just yesterday, I had to spend about 10 minutes locating the Ukranian province of Crimea on a map. For those who have not been keeping track, after days of civil unrest that left some 75 protesters dead, Ukrainian President Viktor Yanukovych fled the capital city of Kiev and agreed with opposition leaders to reduce his powers and hold early presidential elections later this year. For context, in 1954, the former Soviet Union leader Nikita Khrushchev transferred Crimea from the Russian Soviet republic to Ukraine on the basis of economic ties that were closer with Kiev than with Moscow. Prior to that transfer, Russia seized Crimea from the declining Ottoman Empire in the 18th century. Fast forward to today, and fresh off a successful Olympics in Sochi, Russia, Russian President Vladimir Putin hasn’t been happy about the citizen uprising in neighboring Ukraine, so he has decided to flex his muscles and move Russian troops into Crimea. The situation is very fluid and the U.S., along with other global leaders, are crying foul. Time will tell if this situation escalates into a military conflict like the 2008 Georgia-Russia crisis, or if cooler heads prevail.
- Fed Policy Concerns: Federal Reserve Chair Janet Yellen gave her inaugural address last month before Congress, where she signaled continuity in policy with former Fed Chair Ben Bernanke. Indications remain strong that the reduction of bond buying stimulus (i.e., “tapering”) will continue in the months ahead, despite mixed economic results. The “Polar Vortex” occurring on the East Coast, coupled with a record draught on the West Coast contributed to the recent reduction of Q4-2013 GDP growth figures, which were revised lower to +2.4% growth (from +3.2%).
- Domestic Politics: In a sharply politically divided country like the U.S., is there ever a complete hugs & kisses consensus? In short, “no”. How can there be 100% agreement when sharply divisive issues like Obamacare, immigration, tax reform, entitlements, budgets, and foreign affairs are always in flux? Layer on a Congressional midterm election this November and you have a recipe for uncertainty.
Because of all this uncertainty, there are still literally trillions of dollars in cash sitting on the sidelines, waiting to come join the fun. But uncertainty is a relative term because there is always doubt surrounding geopolitics, economics, and Washington D.C. Sentiment moves like a pendulum from fear to greed. Eventually panic/fear sways back the other direction as business/consumer confidence overshadow the deep scarred emotions of 2008-09. As the stock markets have grinded to record highs, fear and skepticism have slowly begun to erode.
Sidoxia Uncertainty
Speaking of uncertainty, I too encountered many doubters and skeptics when I started my firm, Sidoxia Capital Management, LLC in early 2008. Great timing, I thought at the time, as our economy entered the worst recession and financial crisis in a generation and the walls of our nation’s financial system were caving in.
With virtually no company assets or revenues at the time, this was the backdrop as I embarked on my entrepreneurial journey. Seemingly secure investment banking pillars like Bear Stearns and Lehman Brothers, which each had been around for more than a century, crumbled within the blink of an eye. As bailouts were occurring left and right, in conjunction with recurring multi-hundred point collapses in the Dow Jones Industrial index, cynics would repeatedly ask me, “Wade it’s great that you have a lot of experience, but how are you going to gain clients?” It was a fair and reasonable question at the time, but perseverance and hard work have allowed Sidoxia to beat the odds. Publishing several books, conducting numerous media appearances, and gaining thousands of social media followers (InvestingCaffeine.com) hasn’t hurt in building Sidoxia’s brand either.
After achieving record growth in the first five years of the firm, Sidoxia more than doubled its assets under management again in 2013. More important than all of the previously mentioned achievements has been our ability to service our clients with a disciplined, customized process that has demonstrated strong long-term results and helped solidify our valued relationships.
A Few Party Animals Getting Reckless at the Stock Party
Success for Sidoxia or any investor has not come easy over the last six years. As I wrote in a Series of Unfortunate Events, we’ve had to navigate our clients’ investment assets through the following events and more:
- Flash Crash
- Debt Ceiling Debates-Brinksmanship
- U.S. Debt Downgrade
- European Recession
- Arab Spring – Tunisia, Libya, Egypt
- Greek Crisis and Potential Exit from EU
- Uncertain U.S. Presidential Elections
- Sequestration
- Cyprus Financial Crisis
- Income Tax Hikes
- Federal Reserve Tapering
- Syrian Civil War / Military Threat
- Government Shutdown
- Obamacare & Its Glitches
- Iranian Nuclear Threat
- Argentinian Currency Collapse
- Polar Vortex
- Ukrainian Instability
It is no small feat that stock markets have made new records in the face of these daunting concerns. But simply ignoring scary headlines won’t earn you an investing trophy. Successful investing also requires controlling temptation and greed. At a celebratory bash, there are always irresponsible party animals, just like there are always reckless speculators gambling in the financial markets. It certainly is possible to party responsibly without getting crazy during festivities and still have fun. Even though the majority of investors currently are behaving well, as substantiated by the reasonable P/E ratio being paid (15x’s estimated 2014 profits) there are a few foolish players. Pockets of speculative fervor can be found in several areas of the financial markets. Here are a few:
- Bitcoin Breakdown: The world’s largest Bitcoin exchanged filed for bankruptcy after it lost 750,000 Bitcoin units, worth about $477,000,000, based on current exchange rates. The popularity of this speculative virtual currency seems eerily similar to the great Dutch Tulip-Mania of the 1630s.
- Biotech Bliss: Ignorance is a bliss, and apparently so is buying biotech stocks. There’s no need to speculate on gold or Bitcoins when you can invest in the Biotechnology Index (BTK), which has already advanced +21% this year on top of a 51% gain in 2013. Over the last 5+ years, the index has more than quadrupled.
- Facebook Folly: WhatsApp with Facebook Inc’s (FB) $19 billion acquisition of the cellphone texting company? CEO Mark Zuckerberg is claiming he got a bargain by paying almost 1,000x’s the estimated annual revenue of WhatsApp ($20 million). When only a fraction of the 450 million users are paying for the service, I’m OK going out on a limb and calling this deal kooky.
- High Ticket Tesla: Tesla Motors Inc (TSLA) has become a cult stock. The company has a price tag of $30 billion despite burning $7 million in cash last year. The announcement of a $4-5 billion battery “Gigafactory” added to the company’s recent hype. To put things into perspective, General Motors (GM) has revenues 75x’s larger than Tesla and GM generated over $5 billion in 2013 free cash flow. Nevertheless, GM is only valued at 1.9x’s the market value of Tesla…head scratch.
- Social Media Silliness: Maybe not quite as wacky as the $19 billion price tag paid for WhatsApp, but the $30 billion value placed on Twitter Inc (TWTR) for a company that burned $30 million of cash in their most recent financial report is silly too. Yelp Inc (YELP) is another multi-billion valued company that is losing money. I love all these services, but great services don’t always make great stocks. Investors from the dot-com era vividly remember what happened to those overvalued stocks once the bubble burst.
Fear and greed are omnipresent, and some of these speculative areas may continue to appreciate in value. However, controlling or ignoring the powerful emotions of fear and greed will help you in achieving your financial goals. As the markets (and Sidoxia’s team) expand, our disciplined investment process should allow us to objectively identify attractive investment opportunities without succumbing to the pitfalls of panic-selling or performance-chasing.
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DISCLOSURE: Sidoxia Capital Management (SCM) and some of its clients hold positions in certain exchange traded funds (ETFs), but at the time of publishing SCM had no direct position in FB, TWTR, YELP, TSLA, BTK, or any other security referenced in this article. No information accessed through the Investing Caffeine (IC) website constitutes investment, financial, legal, tax or other advice nor is to be relied on in making an investment or other decision. Please read disclosure language on IC Contact page.
Investing Caffeine 
